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(DMP)DAB–Pd–MAH: A Versatile Pd(0) Source for Precatalyst Formation, Reaction Screening, and Preparative-Scale Synthesis

Jingjun Huang, Matthew Isaac, Ryan Watt, Joseph Becica, Emma Dennis, Makhsud I. Saidaminov, William A. Sabbers, David Leitch

Version 1 posted 20 January 2021

1,493

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Chemistry

Working Paper

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

benjamin eduful, Sean O'Byrne, Louisa Temme, Christopher R. M. Asquith, Yi Liang, Alfredo Picado, Joseph Pilotte, Carrow Wells, William Zuercher, Carolina Catta-Preta, Priscila Zonzini Ramos, André Santiago, rafael Counago, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M. Willson, Daniel E Frigo, John W. Scott, David Drewry

Version 1 posted 28 December 2020

887

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Chemistry

Working Paper

Quantitative Prediction of Selectivity in Iridium-Catalysed Hydrogen Isotope Exchange Reactions

Daria Timofeeva, David Lindsay, William Kerr, David Nelson

Version 1 posted 02 July 2020

465

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Chemistry

Working Paper

Control of Stereoselectivity in Diverse Hapalindole Metabolites Is Mediated by Cofactor Induced Combinatorial Pairing of Stig Cyclases

Shasha Li, Sean A. Newmister, andrew n. lowell, Jiachen Zi, Callie R. Chappell, Fengan Yu, Robert M. Hohlman, Jimmy Orjala, Robert M. Williams, David H. Sherman

Version 1 posted 25 October 2019

522

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Chemistry

Working Paper

Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase

Qingyun Dan, Sean A. Newmister, Kimberly R. Klas, Amy E. Fraley, Timothy J. McAfoos, Amber D. Somoza, James D. Sunderhaus, Ying Ye, Vikram V. Shende, Fengan Yu, Jacob N. Sanders, W. Clay Brown, Le Zhao, Robert S. Paton, K. N. Houk, Janet L. Smith, David H. Sherman, Robert M. Williams

Version 1 posted 26 December 2018

1,409

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Chemistry

Working Paper

Synthesis and Styrene Copolymerization of Novel Ring-Disubstituted Isopropyl Cyanoarylacrylates

Paige M. Whelpley, Sejla Bajramovic, Destiny M. Bracamontes, Garrett A. Buechner, Alexander D. Eremin, Erik J. Kowalczyk, David D. Lender, Rachel McCann, William S. Schjerven, Gregory Kharas

Version 1 posted 24 September 2019

702

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Chemistry

Working Paper

Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

Marat Korsik, Edwin Tse, David Smith, William Lewis, Peter J. Rutledge, Matthew Todd

Version 1 posted 06 May 2020

892

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2

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Chemistry

Working Paper

Cofactor-Independent Pinacolase Directs Non-Diels-Alderase Biogenesis of the Brevianamides

Ying Ye, Lei Du, Xingwang Zhang, Sean A. Newmister, Wei Zhang, Shuai Mu, Atsushi Minami, Morgan McCauley, Juan V. Alegre-Requena, Amy E. Fraley, Maria L. Adrover-Castellano, Nolan Carney, Vikram V. Shende, Hideaki Oikawa, Hikaru Kato, Sachiko Tsukamoto, Robert S. Paton, Robert M. Williams, David H. Sherman, Shengying Li

Version 1 posted 29 July 2019

1,238

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1

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Chemistry

Working Paper

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Alfredo Picado, Apirat Chaikuad, Carrow Wells, Safal Shrestha, William Zuercher, Julie E. Pickett, Frank Kwarcinski, Parvathi Sinha, Chandi de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Drewry, Tim Willson

Version 1 posted 07 July 2020

1,153

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Chemistry

Working Paper

Design of BET Inhibitor Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

Farrukh Vohidov, Jannik N. Andersen, Kyriakos D. Economides, Michail V. Shipitsin, Olga Burenkova, James C. Ackley, Bhavatarini Vangamudi, Nolan M. Gallagher, Peyton Shieh, Matthew R. Golder, Jenny Liu, William K. Dahlberg, Hung V.-T. Nguyen, Deborah J. C. Ehrlich, Julie Kim, Sung Jin Huh, Allison M. Neenan, Joelle Baddour, Sattanathan Paramasivan, Elisa de Stanchina, Gaurab KC, David J. Turnquist, Jennifer K. Saucier-Sawyer, Paul W. Kopesky, Samantha W. Brady, Michael J. Jessel, Lawrence A. Reiter, Donald E. Chickering, Jeremiah Johnson, Peter Blume-Jensen

Version 1 posted 17 November 2020

945

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100 results in David Williams in Authors: David Williams

(DMP)DAB–Pd–MAH: A Versatile Pd(0) Source for Precatalyst Formation, Reaction Screening, and Preparative-Scale Synthesis

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

Quantitative Prediction of Selectivity in Iridium-Catalysed Hydrogen Isotope Exchange Reactions

Control of Stereoselectivity in Diverse Hapalindole Metabolites Is Mediated by Cofactor Induced Combinatorial Pairing of Stig Cyclases

Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase

Synthesis and Styrene Copolymerization of Novel Ring-Disubstituted Isopropyl Cyanoarylacrylates

Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

Cofactor-Independent Pinacolase Directs Non-Diels-Alderase Biogenesis of the Brevianamides

A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

Design of BET Inhibitor Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

100 results in Authors: David Williams