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Diffusion Enhanced Amide Bond Formation on Solid Support

04 September 2019, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Performing amino acids coupling reactions on solid support using fast overhead stirring is far more efficient than the common shaking mixing methods. Stirring does not harm the polystyrene beads and allows to decrease dramatically the amount of reagents used and wasted in these transformations.

Keywords

SPPS
Diffusion
Amide Bond Formation

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Now Published

Diffusion-Enhanced Amide Bond Formation on a Solid Support [opens in a new tab]
Johnny N. Naoum, Israel Alshanski, Agata Gitlin-Domagalska, Moshe Bentolila, Chaim Gilon, Mattan Hurevich journal article
Organic Process Research & Development , Volume 23, Issue 12
Online publication date: Nov 08, 2019

Version History

Sep 04, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.9757511.v1
D O I: 10.26434/chemrxiv.9757511.v1 [opens in a new tab]

Author’s competing interest statement

The authors declare no conflict of interest

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