DASS App: Integrating data from non-animal test methods to predict skin sensitization hazard and potency

Chemically induced skin sensitization is a common occupational and public health issue. Regulatory authorities require an assessment of potential to cause skin sensitization for many chemical products. Defined approaches for skin sensitization (DASS) can identify potential chemical skin sensitizers without using animal tests. While several DASS are internationally accepted by regulatory agencies, the data interpretation procedures vary in logical complexity, and manual application can be time-consuming or prone to error. We developed the DASS App, an open-source web application, to facilitate user application of these regulatory testing strategies without the need for software downloads or computational expertise. The web application is freely available at https://ntp.niehs.nih.gov/go/952311. All scripts are available on GitHub (https://github.com/NIEHS/DASS).