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Prothrombin and factor V polymorphisms in a Latin American cohort with heart failure and type 2 diabetes.

10 October 2023, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Introduction : The study of the role of genetic markers of hemostasis disorders in CHF with both preserved (HFPEF) and reduced (HFREF) LVEF in patients with DM2 has not been adequately addressed . Methods : We used “ Genetics of Hemostasis ” kits from the company DNA Technology (USA). Amplification was performed in a DT-Prime 5 amplifier (DNA Technology , USA) for the prothrombin and factor V gene polymorphisms. Results: F13 (rs5985) and fibrinogen (rs1800790): they are more common in patients with HFPEF and DM2 than in the control group and in patients with HFREF ; ITGA2 (rs1126643): was less common in the HFPEF group than in the control group; ITGB3 (rs5918) and PAI-1 (rs1799889) rs5918 are more common than in the control group and HFPEF group. Conclusions : We encourage carrying out this type of studies since they are scarce in the regional literature.

Keywords

Diabetes Mellitus
Polymorphism
Prothrombin
Heart Failure

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Version History

Oct 10, 2023 Version 1

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The content is available under CC BY NC SA 4.0 [opens in a new tab]

DOI

10.33774/coe-2023-10cgn
D O I: 10.33774/coe-2023-10cgn [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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