Abstract
Objective: To assess the cardiometabolic profile and cardiovascular risk factors in women with a history of arterial hypertension (HTN) during pregnancy. Materials and methods: an observational case-control study based on a prospective cohort study included 66 women divided into two groups: group I - with a history of hypertension during pregnancy (n=33), group II (control) - with history of normotensive pregnancies (n=33). We used a propensity score matching method. Results: in the structure of cardiometabolic risk factors in women in group I, hypertension and obesity more often prevailed in comparison with the control group. When assessing the cardiometabolic profile, the highest values among women in group I were found for the levels of glucose and immunoreactive insulin, glycated blood hemoglobin, uric acid, alanine aminotransferase, aspartic aminotransferase, C-reactive protein and the value of the insulin resistance index (HOMA-IR). Among women in group I, the values of the left ventricular myocardial mass index, albumin and albumin/creatinine ratio in the morning urine were higher, and left ventricular hypertrophy and an increase in the albumin/creatinine ratio above 3.5 mg/mmol were more often detected in comparison with group II. Conclusion: After applying the propensity score matching method, the most significant between-group differences were obtained in the presence of hypertension, serum concentrations of alanine aminotransferase, C-reactive protein and the frequency of detection of elevated albumin/creatinine ratio.