Advancing Early Detection in Bipolar Disorder: The Role of Circadian Rhythms

At the International Society for Bipolar Disorders conference in Iceland, Prof Ian Hickie, Co-Director of the Brain and Mind Centre at the University of Sydney, highlighted the significance of circadian rhythms in bipolar disorder. Variabilities in light exposure, motor activation, and metabolic changes, such as insulin resistance, are seen as critical factors in identifying early signs of bipolar disorder. Prof Hickie stresses the importance of early intervention, particularly in youth, a focus often overlooked in bipolar research. Also, input from individuals with lived experience has underscored significant gaps in mental health services for younger patients. Future research goals include advancing global collaborations and leveraging digital technologies —such as wearables that monitor sleep, activity, and body temperature—to improve identification of at-risk individuals.