Assessing the clinical utility of pupillary light reflex in youth with emerging mood disorders
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This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.
Comments
Do you feel as if the norepinephrine system plays a significant role in this? Given the rapid emergency of interest and implications of the locus coeruleus ( and pupil responses in relation to tonic/phasic release of norepinephrine) in modulating cortical states and it's relation to circadian modulation and social rhythms; I'm wondering if pupil changes reflect early signs of arousal and attentional changes in youth with bipolar spectrum and depressive disorders. I'm also wondering if circadian rhythm disruptions are secondary to changes in arousal/ norepinephrine driven changes in cortical excitability, along with a potential contributing role of abnormal reward processing adaptation induced by these initial changes in the norepinephrine system being responsible for the furthering decline in functioning. If my questions are beyond the scope of your paper or seem too invasive, feel free to decline answering!
