Integrating the LC into cortical computation. Current trends, challenges, and future directions.

01 January 2025, Version 3
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

In this review, I cover the role of the LC (Locus coeruleus) in the evolution of dynamic cortical states and the coupling of LC activity to global evolutions of the cortex in response to relevant environmental contingency and behavioral states. I examine the work done Predictive coding and the underlying representational geometries of predictions and error signals that exist across the cortex. Important to note; I do assume these geometries converge towards an optimized global state of the cortex along a given gradient. Furthering discussion, I review current work on the LC and high level representation in cortical networks, along with spatiotemporal dynamics of the system in relation to computational processing of distributed information.

Keywords

Predictive Coding
Neural Ensembles
Locus Coeruleus
spatial computation
Latent states

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Comment number 1, DYLAN CATO: Jan 01, 2025, 09:57

In the section" Features and domain specific representations in brain evolution.."; I erroneously used perturbative in place of data dimensionality reductions for the summary of the paper on 2d representations of sensory domains in hierarchal processing as well as forgetting to briefly summarize pertubative approaches in cross frequency coupling in LC modulation and the concluding remarks section. My attention was fixated on pertubation theory in coupling of multiple quantum bodies and unitary operators, so I seemed to have goofed in two sentences of my manuscript. Overall I'm satisfied for now, I'll post a final version once the manuscript passes peer review. In the meantime, I'm happy to answer any questions and would love some (constructive) criticism or any literature/ research i may have overlooked In this review.

Response,
DYLAN CATO :
Jan 01, 2025, 10:00

Also accidentally imported a reference into my zotero bibliography that i decided not to use in this review.